Burré Laboratory

Publications

2025

  • Gao V*, Chlebowicz J*, Gaskin K*, Briano JA, Komer LE, Pineda A, Jhalani S, Ahmad S, Uwaifo E, Black LS, Haller JE, Przedborski S, Lane DA, Zhang S, Sharma M, Burré J. Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy. Nature Communications, in press. [* equal contribution]
  • Li D, Liu K, Li D, Brunger AT, Liu C, Burré J, Diao JJ. The Synaptic Symphony: How α-Synuclein Orchestrates Synaptic Vesicle Function and Implications for Disease. Trends in Cell Biology, in press.

2024

  • Wang C, Zhao C, Hu X, Qiang J, Liu Z, Gu J, Zhang S, Li D, Zhang Y, Burré J, Diao J, Liu C. N-acetylation of a-synuclein enhances synaptic vesicle clustering mediated by a-synuclein and lysophosphatidylcholine. Elife, 13:RP97228. Pubmed
  • Grinspan ZM, Burré J, Cross J, Ross ME, Stone A, Basma N, Gao K, Kang J-Q, Lim J, Dubow E, Abila M, Miele A, Demarest S. 4-Phenylbutyrate for STXBP1 and SLC6A1. Safety, tolerability, seizure, and EEG outcomes. A case series at 2 centers. medRxiv.
  • Iannone AF, Akgül G, Zhang R, Wacks S, Hussein N, Macias CG, Donatelle A, Bauriedel JMJ, Wright C, Abramov D, Johnson MA, Govek EE, Burré J, Milner TA, De Marco García NV. The chemokine Cxcl14 regulates interneuron differentiation in layer I of the somatosensory cortex. Cell Reports, 43: 114531. Pubmed
  • Burré J, Edwards RH, Halliday G, Lang AE, Lashuel HA, Melki R, Murayama S, Outeiro TF, Papa SM, Stefanis L, Woerman AL, Surmeier JD, Kalia LV, Takahashi R, and the MDS Scientific Issues Committee. Research Priorities on the Role of α-Synuclein in Parkinson’s Disease Pathogenesis. Movement Disorders, online ahead of print. Pubmed
  • Wang C, Zhang K, Cai B, Haller JE, Carnazza KE, Hu J, Zhao C, Tian Z, Hu X, Hall D, Qiang J, Hou, S, Liu Z, Gu J, Zhang Y, Seroogy KB, Burré J, Fang Y, Liu C, Brunger AT, Li D, Diao J. VAMP2 chaperones a-synuclein in synaptic vesicle co-condensates. Nature Cell Biology, online ahead of print. Pubmed
  • Wang C, Zhao C, Hu X, Qiang J, Liu Z, Gu J, Zhang S, Li D, Zhang Y, Burré J, Diao J, Liu C. N-acetylation of a-synuclein enhances synaptic vesicle clustering mediated by a-synuclein and lysophosphatidylcholine. BioRxiv, posted March 2024. doi: 10.1101/2024.03.04.583437 (Link).
  • Gao V, Crawford CV, Burré J. The gut-brain axis in Parkinson’s Disease. Cold Spring Harbor Perspectives in Medicine, May 21:a041618, online ahead of print. Pubmed
  • Guiberson NGL, Black LS*, Haller JE*, Brukner A, Abramov D, Ahmad S, Xie YX, Sharma M, Burré J. Disease-linked mutations in Munc18-1 deplete synaptic Doc2. Brain, 147(6):2185-2202 (* equal contribution). Pubmed

2023

  • Lai Y, Zhao C, Tian Z, Wang C, Fan J, Hu X, Tu J, Li T, Leitz J, Pfuetzner RA, Liu Z, Zhang S, Su Z, Burré J, Li D, Südhof TC, Zhu Z-J, Liu C, Brunger AT, Diao J. Neutral lysophosphatidylcholine mediates a-synuclein-induced synaptic vesicle clustering. PNAS, 120(44): e2310174120. Pubmed 

2022

  • Sharma M and Burré J. α-Synuclein in synaptic function and dysfunction. Trends in Neurosciences, 46(2): 153. [invited review] Pubmed
  • Xie YX, Naseri NN, Fels J, Kharel P, Na Y, Lane D, Burré J, Sharma M. Lysosomal Exocytosis Releases Pathogenic α-Synuclein Species from Neurons in Synucleinopathy Models. Nature Communications, 13(1): 4918. Pubmed
  • Burré J and Sharma M. Cellular and small animal models of neurodegenerative diseases. Editorial, Journal of Visualized Experiments, Aug 17:(186). Pubmed
  • Gao V, Briano JA, Komer LE, Burré J. Functional and pathological effects of alpha-synuclein on synaptic SNARE complexes. Journal of Molecular Biology, online ahead of protein & part of special issue “Protein membrane interactions at the synapse”. [invited review] Pubmed
  • Carnazza KE*, Komer L*, Xie YX, Pineda A, Briano JA, Gao V, Na Y, Ramlall T, Buchman VL, Eliezer D, Sharma M, Burré J. Synaptic vesicle binding of alpha-synuclein is modulated by beta- and gamma-synucleins. Cell Reports, 39(2): 110675. [*equal contribution] Pubmed

2021

  • Xie YX, Naseri NN, Fels J, Kharel P, Na Y, Burré J, Sharma M. Lysosomal exocytosis releases pathogenic alpha-synuclein species from neurons. BioRxiv, posted April 2021. doi: https://doi.org/10.1101/2021.04.10.439302 (Link)
  • Abramov D, Guiberson NGL, Daab A, Na Y, Petsko GA, Sharma M, Burré J. Targeted stabilization of Munc18-1 function via pharmacological chaperones. EMBO Molecular Medicine, 13(1): e12354 (2021). Pubmed
  • Abramov D*, Guiberson NGL*, Burré J. STXBP1 encephalopathies: Clinical Spectrum, Disease Mechanisms and Therapeutic Strategies. The Journal of Neurochemistry, 1572(2): 165-178 (2021). [* equal contribution] Pubmed

2020

  • Carnazza KE, Komer L, Pineda A, Na Y, Ramlall T, Buchman VL, Eliezer D, Sharma M, Burré J. Beta- and gamma-synucleins modulate synaptic vesicle-binding of alpha-synuclein. BioRxiv, posted November 2020. doi: https://doi.org/10.1101/2020.11.19.390419 (Link)
  • Naseri NN, Ergel B, Kharel P, Na Y, Huang Q, Huang R, Dolzhanskaya N, Burré J, Velinov MT, Sharma M. Aggregation  of Mutant Cysteine String Protein-a via Fe-S Cluster-Binding is mitigated by Fe-chelators. Nature Structural & Molecular Biology, 27: 192 (2020). Pubmed

2018

  • Guiberson NGL*, Pineda A*, Abramov D, Kharel P, Carnazza KE, Wragg R, Dittman JS, Burré J. Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones. Nature Communications, 9: 3986 (2018). [* equal contribution] Pubmed  
  • Burré J, Sharma M, Südhof TC. Cell Biology and Pathophysiology of α-Synuclein. Cold Spring Harbor Perspectives in Medicine, 8 (2018). Pubmed

2017

  • Pineda A, Burré J. Modulating membrane binding of α-synuclein as a therapeutic strategy. PNAS, 114: 1223-1225 (2017). Pubmed

2015

  • Burré J. The Synaptic Function of α-Synuclein. Journal of Parkinson’s Disease, 5: 699-713 (2015). Pubmed
  • Bacaj T, Wu D, Burré J, Malenka RC, Liu X, Südhof TC. Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. PLOS Biology, 13: e1002267 (2015). Pubmed
  • Burré J, Sharma M, Südhof TC. Definition of a molecular pathway mediating α-synuclein neurotoxicity. The Journal of Neuroscience, 35: 5221-5232 (2015). Pubmed

2014

  • Burré J, Sharma M, Südhof TC. α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. PNAS, 111: E4274-4283 (2014). Pubmed
  • Acuna C, Guo Q, Burré J, Sharma M, Sun J, Südhof TC. Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca2+ sensitivity. Neuron, 82: 1088-1100 (2014). Pubmed

2013

  • Burré J*, Vivona S*, Diao JJ, Sharma M, Brunger AT, Südhof TC. Properties of native brain α-synuclein.  Nature, 498: E4 (2013). [*equal contribution] Pubmed
  • Diao JJ*, Burré J*, Vivona S, Sharma M, Südhof TC, Brunger AT. Native α-synuclein induces clustering of synaptic vesicle-mimics via binding to phospholipids and synaptobrevin-2/VAMP2. eLIFE, 2: e00592 (2013).  [*equal contribution] Pubmed

2012

  • Burré J, Sharma M, Südhof TC. Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities. The Journal of Neuroscience, 32: 15227-15242 (2012). Pubmed
  • Sharma M, Burré J, Südhof TC. Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration. Science Translational Medicine, 4:147ra113 (2012). Pubmed
  • Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC. CSPα knockout causes neurodegeneration by impairing SNAP-25 function. The EMBO Journal, 31: 829-841 (2012). Pubmed

2011

  • Sharma M, Burré J, Südhof TC. CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nature Cell Biology, 13: 30-39 (2011). Pubmed

2010

  • Burré J*, Sharma M*, Tsetsenis T, Buchman V, Etherton MR, Südhof TC. α-Synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 329: 1663-1667 (2010). [*equal contribution] Pubmed

2009

  • Burré J, Wittig I, Schägger H. Non-classical 2-D electrophoresis. Methods in Molecular Biology, 564: 33-57 (2009). Pubmed

2007

  • Burré J, Zimmermann H, Volknandt W. Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter. Journal of Neurochemistry, 103: 276-287 (2007). Pubmed
  • Burré J, Volknandt W. The synaptic vesicle proteome. Journal of Neurochemistry, 101: 1448-62 (2007). Pubmed
  • Burré J, Zimmermann H, Volknandt W. Immunoisolation and subfractionation of synaptic vesicle proteins. Analytical Biochemistry, 362: 172-81 (2007). Pubmed

2006

  • Burré J, Beckhaus T, Schägger H, Corvey C, Hofmann S, Karas M, Zimmermann H, Volknandt W. Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques. Proteomics, 6: 6250-6262 (2006). Pubmed
  • Burré J, Beckhaus T, Corvey C, Karas M, Zimmermann H, Volknandt W. Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis. Electrophoresis, 27: 3488-3496 (2006). Pubmed

2005

  • Morciano M*, Burré J*, Corvey C, Karas M, Zimmermann H, Volknandt W. Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis. Journal of Neurochemistry 95: 1732-1745 (2005). [*equal contribution] Pubmed