Burré Laboratory



  • Sharma M and Burré J. α-Synuclein in synaptic function and dysfunction. Trends in Neurosciences. In press. [invited review]
  • Xie YX, Naseri NN, Fels J, Kharel P, Na Y, Lane D, Burré J, Sharma M. Lysosomal Exocytosis Releases Pathogenic α-Synuclein Species from Neurons in Synucleinopathy Models. Nature Communications, 13(1): 4918. Pubmed
  • Burré J and Sharma M. Cellular and small animal models of neurodegenerative diseases. Journal of Visualized Experiments, Editorial, Link.
  • Gao V, Briano JA, Komer LE, Burré J. Functional and pathological effects of alpha-synuclein on synaptic SNARE complexes. Journal of Molecular Biology, online ahead of protein & part of special issue “Protein membrane interactions at the synapse”. [invited review] Pubmed
  • Carnazza KE*, Komer L*, Xie YX, Pineda A, Briano JA, Gao V, Na Y, Ramlall T, Buchman VL, Eliezer D, Sharma M, Burré J. Synaptic vesicle binding of alpha-synuclein is modulated by beta- and gamma-synucleins. Cell Reports, 39(2): 110675. [*equal contribution] Pubmed


  • Xie YX, Naseri NN, Fels J, Kharel P, Na Y, Burré J, Sharma M. Lysosomal exocytosis releases pathogenic alpha-synuclein species from neurons. BioRxiv, posted April 2021. doi: https://doi.org/10.1101/2021.04.10.439302 (Link)
  • Abramov D, Guiberson NGL, Daab A, Na Y, Petsko GA, Sharma M, Burré J. Targeted stabilization of Munc18-1 function via pharmacological chaperones. EMBO Molecular Medicine, 13(1): e12354 (2021). Pubmed
  • Abramov D*, Guiberson NGL*, Burré J. STXBP1 encephalopathies: Clinical Spectrum, Disease Mechanisms and Therapeutic Strategies. The Journal of Neurochemistry, 1572(2): 165-178 (2021). [* equal contribution] Pubmed


  • Carnazza KE, Komer L, Pineda A, Na Y, Ramlall T, Buchman VL, Eliezer D, Sharma M, Burré J. Beta- and gamma-synucleins modulate synaptic vesicle-binding of alpha-synuclein. BioRxiv, posted November 2020. doi: https://doi.org/10.1101/2020.11.19.390419 (Link)
  • Naseri NN, Ergel B, Kharel P, Na Y, Huang Q, Huang R, Dolzhanskaya N, Burré J, Velinov MT, Sharma M. Aggregation  of Mutant Cysteine String Protein-a via Fe-S Cluster-Binding is mitigated by Fe-chelators. Nature Structural & Molecular Biology, 27: 192 (2020). Pubmed


  • Guiberson NGL*, Pineda A*, Abramov D, Kharel P, Carnazza KE, Wragg R, Dittman JS, Burré J. Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperonesNature Communications, 9: 3986 (2018). [* equal contribution] Pubmed  
  • Burré J, Sharma M, Südhof TC. Cell Biology and Pathophysiology of α-Synuclein. Cold Spring Harbor Perspectives in Medicine, 8 (2018). Pubmed


  • Pineda A, Burré J. Modulating membrane binding of α-synuclein as a therapeutic strategy. PNAS, 114: 1223-1225 (2017). Pubmed


  • Burré J. The Synaptic Function of α-Synuclein. Journal of Parkinson’s Disease, 5: 699-713 (2015). Pubmed
  • Bacaj T, Wu D, Burré J, Malenka RC, Liu X, Südhof TC. Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. PLOS Biology, 13: e1002267 (2015). Pubmed
  • Burré J, Sharma M, Südhof TC. Definition of a molecular pathway mediating α-synuclein neurotoxicity. The Journal of Neuroscience, 35: 5221-5232 (2015). Pubmed


  • Burré J, Sharma M, Südhof TC. α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. PNAS, 111: E4274-4283 (2014). Pubmed
  • Acuna C, Guo Q, Burré J, Sharma M, Sun J, Südhof TC. Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca2+ sensitivity. Neuron, 82: 1088-1100 (2014). Pubmed


  • Burré J*, Vivona S*, Diao JJ, Sharma M, Brunger AT, Südhof TC. Properties of native brain α-synucleinNature, 498: E4 (2013). [*equal contribution] Pubmed
  • Diao JJ*, Burré J*, Vivona S, Sharma M, Südhof TC, Brunger AT. Native α-synuclein induces clustering of synaptic vesicle-mimics via binding to phospholipids and synaptobrevin-2/VAMP2. eLIFE, 2: e00592 (2013).  [*equal contribution] Pubmed


  • Burré J, Sharma M, Südhof TC. Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities. The Journal of Neuroscience, 32: 15227-15242 (2012). Pubmed
  • Sharma M, Burré J, Südhof TC. Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration. Science Translational Medicine, 4:147ra113 (2012). Pubmed
  • Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC. CSPα knockout causes neurodegeneration by impairing SNAP-25 function. The EMBO Journal, 31: 829-841 (2012). Pubmed


  • Sharma M, Burré J, Südhof TC. CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nature Cell Biology, 13: 30-39 (2011). Pubmed


  • Burré J*, Sharma M*, Tsetsenis T, Buchman V, Etherton MR, Südhof TC. α-Synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 329: 1663-1667 (2010). [*equal contribution] Pubmed


  • Burré J, Wittig I, Schägger H. Non-classical 2-D electrophoresis. Methods in Molecular Biology, 564: 33-57 (2009). Pubmed


  • Burré J, Zimmermann H, Volknandt W. Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter. Journal of Neurochemistry, 103: 276-287 (2007). Pubmed
  • Burré J, Volknandt W. The synaptic vesicle proteome. Journal of Neurochemistry, 101: 1448-62 (2007). Pubmed
  • Burré J, Zimmermann H, Volknandt W. Immunoisolation and subfractionation of synaptic vesicle proteins. Analytical Biochemistry, 362: 172-81 (2007). Pubmed


  • Burré J, Beckhaus T, Schägger H, Corvey C, Hofmann S, Karas M, Zimmermann H, Volknandt W. Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques. Proteomics, 6: 6250-6262 (2006). Pubmed
  • Burré J, Beckhaus T, Corvey C, Karas M, Zimmermann H, Volknandt W. Synaptic vesicle proteins under conditions of rest and activation: analysis by 2-D difference gel electrophoresis. Electrophoresis, 27: 3488-3496 (2006). Pubmed


  • Morciano M*, Burré J*, Corvey C, Karas M, Zimmermann H, Volknandt W. Immunoisolation of two synaptic vesicle pools from synaptosomes: a proteomics analysis. Journal of Neurochemistry 95: 1732-1745 (2005). [*equal contribution] Pubmed